TDG anticorps

N° du produit ABIN7467207

Cet anticorps Souris Monoclonal détecte spécifiquement TDG dans WB et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour TDG anticorps (ABIN7467207)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GT311

Détail du produit anti-TDG anticorps

Réactivité croisée: Humain, Souris

Purification: Affinity purified by Protein A.

Immunogène: Recombinant protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary.

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: thymine DNA glycosylase

Sujet: Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]

Poids moléculaire: 46 kDa

ID gène: 6996

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding